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Still, without extensive studies in pregnant humans, these results indicate a need for caution

While current data do not show a causal association between GLP-1 RAs and suicidality, consistent messaging across the class aims to support safe use as prescribing expands for diabetes and obesity

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Sonthalia, Sidharth, et al

Body fat helps produce and store estrogen

The GLP-1 medications it prescribes (Wegovy, Zepbound, oral Wegovy) produced 15-20% average weight loss in pivotal trials