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If gastrointestinal symptoms are severe or persistent, dose reduction or temporary treatment interruption may be necessary
Electron transfer between cytochrome c and microsomal monooxygenase generates reactive oxygen species that accelerates apoptosis
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doi: 10.1016/j.ymeth.2013.07.024 191 MalaninKLundbergMJohanssonSGO
Patients were randomized to follow a therapeutic cycle for a total period of eight years: citicoline (1,000 mg/day, by intramuscular injection) or placebo (-blockers alone) for a two-month period followed by a four-month washout period (87)
On the other hand, in contrast to those enrolled in clinical trials, patients seen in routine clinical practice are allowed to switch between drugs within the same drug class, which could lower rates of treatment discontinuation
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