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One paper focuses on blood flow rescue and colon injury in ischemic colitis
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MOTS-C is a 16-amino-acid peptide that lives inside your mitochondria, where it activates AMPK and pushes cells to burn fat for fuel
Adults aged 40-60 face highest risk, with women 4 times more likely to develop the condition, and diabetics showing 10-20% prevalence compared to 2-5% in the general population
Therefore, a bypassing key, i.e., an activated azygos vein as a rescuing pathway, avoiding both the lung and liver and also noted in BuddChiari syndrome (i.e., suprahepatic occlusion of the inferior caval vein) ( BPC 157s endothelial effects and its function as a bypassing key (Sikiric et al., 2018) are strongly supported by its interaction with the nitric oxide (NO) system (for a review, see Sikiric et al., 2014)
The consistency of preclinical results and the plausible mechanisms give me reasonable confidence that the peptide does something meaningful biologically
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