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This dose titration approach is carefully designed to improve tolerability while achieving therapeutic efficacy

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163 More strikingly, the impact of rilonacept on the treatment paradigm for recurrent pericarditis was further demonstrated in the RHAPSODY (Rilonacept Inhibition of Interleukin-1 alpha and beta for recurrent pericarditis) study, a phase III randomized controlled trial that showed marked clinical efficacy

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However, despite encouraging findings, clinical translation remains limited due to the lack of sufficient human studies, variability in individual responses, and an incomplete understanding of their mechanisms in sepsis

Effect of vitamin C and vitamin E supplementation on endothelial function: a systematic review and meta-analysis of randomised controlled trials