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Curiously, fat-induced OEA synthesis is a fairly conserved pathway in metazoan, being present in fish and extremely slow-metabolism reptiles such as pythons (325, 326)
However, the same research demonstrates that stopping the medication leads to weight regain in most people, suggesting that extended treatment better supports lasting results than short-term use alone
Diabetes Metab J 44:802818 Lonneman DJ, Rey JA, McKee BD (2013) Phentermine/Topiramate Extended-Release Capsules (Qsymia) for Weight Loss
Meanwhile, appetite suppression persists and often deepens over time
up to 1,000 mg for therapeutic needs
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