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Gastro-oesophageal reflux is listed as a common side effect (up to 1 in 10 people) with some GLP-1 medications, particularly during initial dose titration
These are known as small-molecule GLP-1s, whereas injectable versions are large-molecule GLP-1s
People with type 2 diabetes relying on this for glucose control
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Graphical Abstract Scheme 1
In other words, barely 1 in 7 patients remains on GLP-1 therapy after two years , despite obesity being a chronic condition requiring long-term treatment
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