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The rs762551 variant can affect the inducibility of CYP1A2 expression by xenobiotics such as caffeine or cigarette smoking, likely through effects on gene transcription or splicing PubMed Central

doi: 10.1101/cshperspect.a001651 178 MuellerALBrockmuellerAKunnumakkaraABShakibaeiM

And if these tiny toxins begin to accumulate in your cells, they can significantly hinder your ability to produce sufficient levels of glutathione

Wu, G., Fang, Y

That partial separation is the entire reason the two classes complement rather than compete

Injectable Glutathione (IM/SubQ 200-600 mg) Characteristics: Good bioavailability bypasses gut degradation while avoiding the clinic-visit requirement of IV