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According to one study , participants who took a semaglutide injection weekly, combined with lifestyle intervention, saw a 14.9% decrease in body weight over the course of 68 weeks
The safety profile appears favorable for extended use based on available data, though long-term studies specifically on oral formulations do not exist
In parallel, emerging data from male reproductive studies suggest that GLP-1RAs may positively influence the hypothalamic-pituitarytesticular axis, improve testicular function, and enhance spermatogenesis, particularly in obese men
This gradual titration approach is consistent with the prescribing philosophy applied to other incretin-based therapies in the UK, where slow escalation is used to improve tolerability and encourage long-term adherence
Meanwhile, the more obvious association in men has some consistency with higher CVD risk and higher carnitine in men than women [48]
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