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Peptides have existed as potential drug candidates for decades, but the process of linking the amino acids in the correct sequence requiring repeated chemical reactions and purification made them difficult to manufacture and incredibly labor-intensive, Kates said

Presented for research literature review only Naidu GS et al

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This has called for new emerging strategies for improved bioavailability that include chemical modifications to stabilize the peptide, use of enzyme inhibitors, linkage to absorption enhancers, and packaging peptides using nanoparticles

1 2 "-nicotinamide adenine dinucleotide is an enteric inhibitory neurotransmitter in human and nonhuman primate colons"