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A pure glucagon drug would raise blood sugar and be a non-starter

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doi: 10.1016/j.metop.2021.100093 437 ZengYWuYZhangQXiaoX

When you eat, GLP-1 is released to stimulate insulin secretion, slow down gastric emptying, and reduce hunger signals

Occasional alcohol may be reasonable for some people, but heavy drinking is not a good match for a plan focused on metabolic health, appetite regulation, and long-term weight management

However, human data remained mixed, leaving a gap between preclinical fears and clinical reality