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To overcome these inherent limitations (diagnostic criteria variation and potentially missing report of target adverse events), we adopted confirmatory approach based on Cochrane recommendations [32] and strictly focused on RCTs with systematically report of adverse events or explicitly evaluating target outcomes [33]
Torres et al., 2016)
Starting low is not being conservative
These strategies compared to currently available drug medications such as thiazolidinediones, sulphonylureas, and insulin, have the potential to treat diabetes without causing side effects of hypoglycemia and weight gain
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