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Dipeptidyl dipeptidase-4 inhibitors These drugs, consisting primarily of sitagliptin, vildagliptin, linagliptin, saxagliptin, and alogliptin, enhance the effects of incretins by inhibiting dipeptidyl dipeptidase 4 (DPP-4), the enzyme responsible for their degradation
On the contrary, suicidal ideation and outcomes associated with suicide were rated as low to very low
BioWorld Regulatory Cardiovascular Endocrine/metabolic Obesity Small molecule FDA NDA
It may be considered when lower doses have already been used and additional appetite control or weight-loss support may be beneficial
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