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A WHO consultation identified the most vulnerable groups as elderly individuals, infants, preschool-aged children, and pregnant or lactating women, due to either increased nutritional demands or impaired absorption capacity ( Addressing the prevention of B12 deficiency and its public health implications requires a comprehensive, life-course approach based on integrated strategies targeting early detection, dietary optimisation, and effective supplementation, in order to mitigate the long-term consequences of inadequate cobalamin status ( Intramuscular (IM) injection is the most invasive and costly administration method, requiring trained personnel and clinical visits
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However, these agents often lack selectivity, potentially causing unnecessary damage and apoptosis in normal cells (Marcus et al., 2018
BPC 157 application largely counteracted changes at the microscopic level, including the formation of vacuoles and the loss of axons in the white matter, the formation of edema and the loss of motoneurons in the gray matter, and a decreased number of large myelinated axons in the rat caudal nerve from day 7
The relative contribution of these mechanisms remains an open research question
[28] Cases of fulminant liver failure reported with propylthiouracil have led to a regulatory warning, [29] and to guidelines recommending methimazole as the first line anti-thyroid agent
