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The scenarios where injectable GLP-1s are clearly superior: A1C above 9.0% (need for maximum efficacy) Established cardiovascular disease (need for proven MACE reduction) Primary goal is weight loss (need for higher semaglutide exposure) Difficulty with medication adherence (weekly is easier than daily for many patients) Unpredictable morning schedule (can't guarantee empty stomach timing) The decision is patient-specific
doi:10.1002/bit.22318 53
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Its proposed activity involves modulation of central regulatory hubs rather than direct suppression of stress hormones
The protective effect of HO-1 in diabetic retinopathy is not only reflected in the inhibition of inflammation and oxidative stress but also promoted microglia polarization from the M1 state (pro-inflammatory) towards the M2 state (anti-inflammatory) [159]
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