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The overall outcome was that the body weight did not cause a significant impact on the determining of DCM manifestation in mice (SMD -1.74
Affecting approximately 50% of patients with diabetes, DN is predominantly characterized by distal symmetric polyneuropathy, leading to sensory loss, pain, and motor dysfunction, often resulting in diabetic foot ulcers and lower-limb amputations
This effect is achieved through the activation of signaling pathways such as the ERK1/2, PI3K/AKT, and cAMP/PKA/-cat-Ser675 pathways, which are mediated by GLP-1RAs
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