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Evidence from Clinical Trials on Weight Loss and Body Composition Liraglutide-based clinical evidence from the SCALE (Satiety and Clinical Adiposity-Liraglutide Evidence) trials (NCT01272219 and NCT01272232), which included older adults within the adult study population, reported that a 56-week intervention with liraglutide 3 mg/day as an adjunct to lifestyle modification resulted in significant weight loss compared with placebo [41, 42]

Patients with certain genetic variants may experience stronger appetite suppression and correspondingly greater reductions in natural thirst perception, requiring more deliberate hydration protocols

Whole-brain activation signatures of weight-lowering drugs

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In this sense, TZP could represent a breakthrough due to its magnitude of effects on WL, blood pressure, and glycemia

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