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Acknowledgements This work is supported by grants PI15/01857, PI18/01659 and CIBER Fragilidad y Envejecimiento Saludable (CIBERFES) of Instituto de Salud Carlos III (ISCIII), Ministerio de Economa y Competitividad (MINECO), Spain and European Union (EU)

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FIGURE 10 Notably, activators of SIRT1, such as metformin, have demonstrated the ability to inhibit Th17 cell differentiation and downregulate IL-17A and RORt levels by promoting STAT3 deacetylation (Hamaidi and Kim, 2022)

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