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The efficacy and safety were evaluated with open label extension period, switching placebo to pioglitazone 30 mg/day at 48 weeks (ClinicalTrials.gov identifier: NCT05296044)

Males and females were treated with 20 mM BSO (19176, Sigma-Aldrich) in the drinking water starting at 21 days of age, immediately after weaning

MonelliFVenturelliFBonilauriLManicardiEManicardiVRossiPGet al

Molecular mechanisms of immunoinflammatory infiltration and ferroptosis in arthritis revealed by a combination of bioinformatics and single-cell analysis

In addition, alterations in reproductive hormone levelsincluding decreased testosterone and increased LH/FSH ratioshave been documented in diabetic men, further supporting the endocrine disruption described in experimental studies [164, 302]