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This transition can be especially challenging because pregnancy itself becomes progressively insulin-resistant as placental hormones rise

For example, superoxide and H 2 O 2 , two major ROS, are balanced by the corresponding scavengers, superoxide dismutase and catalase, respectively

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Thus, SREBP signaling is essential for metabolic reprogramming in GC and activated B cells

They may help patients feel full sooner and reduce persistent hunger, but results vary and treatment requires medical supervision

Metformin often supports modest weight loss and better blood sugar control, especially in people with insulin resistance or prediabetes