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The most clinically relevant interaction is with oral medications that require consistent absorption timing, since semaglutide slows gastric emptying and can alter how quickly other drugs reach the bloodstream
Some studies report a reduction in alcohol and nicotine intake, whereas results for opioids and stimulant use disorders are less conclusive
Looking ahead, treatment strategies that include GLP-1 receptor agonists may become even more personalized
While acknowledging the strengths of the study, such as participant criteria, low drop-out rates and high adherence, the researchers also acknowledged limitations, including the relatively short intervention duration and the absence of a third intervention group receiving synbiotics alongside a placebo
