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A total of 22 studies (3 in vitro, 8 animal, 11 human observational studies) were included

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3-AR knockout mice: In 3-AR gene knockout mice, the lipolysis effect of AOD 9604 was significantly weakened, confirming that its effect depends on the 3-AR signaling pathway

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One pathway frequently discussed in MOTS-C research is AMP-activated protein kinase, commonly called AMPK