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Since GLP-1 is cleaved by dipeptidyl peptidase-4 and has a half-life of less than 2 minutes, it is likely that intestinal GLP-1, released after eating, exerts its effect on the brain mainly by interacting with vagus afferent neurons located in the porta hepatis and pylorus
Tirzepatide shows similar effects
Wegovy is intended as an adjunct to a reduced-calorie diet and increased physical activity
Dose escalation to twice daily may be considered only after 8 weeks of stability
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Fluctuations in refrigerator temperature can affect the medications chemical stability and shorten its usable life
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