Published preclinical work used a wide range of oral doses
Amylin is a 37amino acid pancreatic hormone co-secreted with insulin from pancreatic beta cells in response to nutrient intake
We found that in wild-type mice, the prolonged fast between meals was necessary for the beneficial effects of a CR diet on metabolic health, frailty, longevity, and cognition 12
J Pharmacol Sci 95:1926 Prkacin I, Separovic J, Aralicia G, Perovic D, Gjurasin M, Lovric-Bencic M, Stancic-Rokotov D, Staresinic M, Anic T, Mikus D et al (2001) Portal hypertension and liver lesions in chronically alcohol drinking rats prevented and reversed by stable gastric pentadecapeptide BPC 157 (PL-10, PLD-116), and propranolol, but not ranitidine
Poor oral bioavailability it breaks down quickly in stomach acid, often requiring subcutaneous injections
For many people, injections are the most effective way to manage a deficiency, particularly where absorption from tablets is limited