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Think of them like intricate biological machinery that can be easily damaged

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524 In the advanced stages of atherosclerotic disease, macrophages destroy the collagen of the fibrous cap and induce smooth muscle cell death by secreting multiple types of inflammatory factors and matrix metalloproteinases (MMPs), thus exacerbating plaque instability

The selected dose (3 mg/kg) is in the intermediate doses range (15 mg/kg) used in rodents studies (Callera et al., 2016) and was selected from previous work from our laboratory (Paz et al., 2013

Martins ML, Souza DDS, Cavalcante M, et al

For travel, use a medical-grade cooling case that maintains 28C