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R., Trakht, I., Srinivasan, V., Spence, D
I completely understand the skepticism because wellness has a lot of noise in it
For example, metalloproteinase inhibitor 4 (TIMP4) was upregulated by semaglutide in STEP 2 but not STEP 1
While the early data is promising: There are no large randomized controlled trials in lipedema Most evidence comes from small studies or related conditions These medications are not currently approved specifically for lipedema However, they may be helpful for some individuals , particularly those with: Insulin resistance Weight gain alongside lipedema Significant inflammation or metabolic dysfunction Why Nutrition Still Matters with GLP-1 Medications GLP-1 medications are not a standalone solution
Woolf EC, Scheck AC
The reason lies in the fact that the clinical trials used obese patients (high body mass index = more fat to reduce), whereas Mounjaro was tested on people with Type 2 diabetes (body mass index may be lower)
