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The breadth of gene expression changes observed has been attributed to GHK-Cus role as a signaling molecule that interacts with multiple cellular systems simultaneously

They proposed that PGH synthase converts arachidonic acid into prostaglandin G 2 and prostaglandin H 2

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Plant-derived phytochemicals show strong chemopreventive activity against breast cancer by selectively modulating important signaling pathways and offering a safer profile than many conventional treatments ( Figure 3 )