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Early, in-depth review article that evaluates the similarities and differences between short-acting and long-acting GLP-1R agonists in terms of glucose-lowering efficacy and adverse effects, and discusses the possibilities for utilizing these agents for individualized treatment of T2DM
2012;7:e48872
tirzepatide: Key differences Lets discuss the key differences between semaglutide and tirzepatide: Mechanism of action Tirzepatide is a dual agonist at GIP and GLP-1 receptors, but semaglutide only acts on GLP-1 receptors
Factors independent of glycaemic and weight loss effects have also been suggested to affect the cardiovascular protective effects of GLP-1RAs
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