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Even mild sleep restriction of just one to two hours can measurably impair insulin sensitivity within days

280 The accumulation of unfolded or misfolded proteins triggers the unfolded protein response (UPR), an adaptive signaling network coordinated by the endoplasmic reticulum sensors IRE1, PERK, and ATF6, which functions to restore proteostasis and maintain cellular homeostasis

Johnson MB, Young AD, Marriott I (2017) The therapeutic potential of targeting substance P/NK-1R interactions in inflammatory CNS disorders

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Long live FOXO: unraveling the role of FOXO proteins in aging and longevity