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Many clinical observations suggest use 2-3 times per week rather than daily, with cycling periods to help maintain response over time
Low fluid intake is the most modifiable risk factor
Deficiencies of vitamin B12 are fairly common but it is difficult to know if you are deficient
However, big pharma will still have the ability to charge premium prices for innovator molecules, especially those with higher efficacy (eg retatrutide) and those aimed at niche patient populations rather than the mass market (eg survodutide, which is targeting MASH endpoints in clinical trials)
your GP or specialist can advise on whether you meet the criteria
When a medication goes through phase 3 clinical trials with that many participants, genuine side effects tend to surface
