Trends in Biochemical Sciences
The most common findings in preclinical work are injection-site irritation, transient redness or warmth at the injection site (often associated with GHK-Cu), and copper-zinc balance considerations on longer protocols
Semaglutide significantly increases the risk of diarrhea (relative risk 2.66 in the meta-analysis), and nausea affects up to 40% of users, particularly during the early weeks of treatment
Antihistamines are thought to counteract nausea by blocking signals to the brain that trigger nausea and vomiting
Both medications share similar gastrointestinal side effect profiles, with mild nausea being the most common symptom during initial dose adjustments
Missed doses fall under different rules 48 hours for Wegovy, 5 days for Ozempic, and immediate skip for oral semaglutide