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ISRN Obes
Although superoxide anion and hydrogen peroxide are not particularly reactive they may synergize with specific factors, eg iron, generating potent free radicals such as hydroxyl radical, which may cause direct injury through alteration of vital cellular macromolecules (DNA, protein or lipids)
Statistics indicate that the risk of lower extremity amputation is 1540 times higher in diabetic patients compared to non-diabetics, with about one million patients undergoing amputation surgeries annually due to foot complications, imposing a heavy burden on patients, families, and healthcare systems (Senneville et al., 2024)
Author Contributions Authors equally contributed to research and preparation of the manuscript
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