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The kind that makes the first two days after injection miserable
Dokadny schemat dawkowania, czstotliwo podawania oraz zasady modyfikacji terapii zostan okrelone dopiero wtedy, gdy lek przejdzie pen procedur rejestracyjn
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A meta-analysis of GLP-1 RAs from trials comprising 56,004 patients found a significant reduction in 3-point MACE (cardiovascular mortality, nonfatal MI, and nonfatal stroke) (HR 0.88, 95% CI 0.790.98), cardiovascular mortality (HR 0.88, 95% CI 0.760.94), all-cause mortality (HR 0.89, 95% CI 0.810.97), fatal and nonfatal stroke (HR 0.84, 95% CI 0.760.94), and HHF (HR 0.92, 95% CI 0.860.97) as well as a trend towards reduction in nonfatal and fatal MI (HR 0.91, 95% CI 0.821.02) [4]
In October 2023, A Research Study to See How Semaglutide Works Compared to Placebo in People with Type 2 Diabetes and Chronic Kidney Disease (FLOW) trial assessing the effect of semaglutide versus placebo on the progression of renal impairment in people with T2DM and chronic kidney disease was stopped prematurely due to results of an interim analysis showing significant efficacy of semaglutide with full results due to be released in the first half of 2024 [39]
