This is a concern that applies to all significant weight loss interventions, not just tirzepatide, but it becomes more relevant as the magnitude of weight loss increases
Dihexa (N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) is a small oligopeptide drug developed from angiotensin IV, a naturally occurring peptide with roles in learning, memory, and blood flow regulation
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Ferroptosis caused by iron accumulation is accompanied by elevated ROS and inflammatory response, insulin resistance and mitochondrial dysfunction, leading to metabolic disorders and the development of obesity (60)
LC-MS identity confirmed (mass 1419.53 Da)
Thus, various tumors, including glioma, secondary glioblastoma, and acute myeloid leukemia (AML), harboring heterozygous point mutations in the active sites of IDH1/2 show dramatic increases in the R-2-HG levels 111,113,114,115