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10.1111/jnc.15200 J

Allison Whitten AstraZeneca reports mixed Phase 3 results across oncology and rare disease AstraZeneca reported mixed late-stage clinical results, with its Claudin 18.2-targeting antibody-drug conjugate sonesitatug vedotin meeting its primary endpoint in patients with previously treated advanced gastric cancer, while rare disease therapy Ultomiris missed the primary endpoint in a Phase 3 trial for thrombotic microangiopathy following haematopoietic stem cell transplantation (HSCT-TMA)

In this study, the semaglutide-metformin combination showed that although no significant difference was observed in overall weight loss between the semaglutide-intensified and standard treatment groups, BMI, waist circumference, hip circumference, and body fat percentage were significantly lower in the semaglutide-intensified group

For intraperitoneal or oral glucose tolerance tests (GTTs), mice were fasted overnight for 1214 hours followed by the administration of glucose (2 g/kg body weight) intraperitoneally or through oral gavage

is a Damon Runyon Fellow supported by the Damon Runyon Cancer Research Foundation (DRG-2431-21)