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Digestive reactions are among the most commonly reported side effects
Adults using a GLP-1 had an increase in GFR from 50.48 mL/min/1.73 m 2 at baseline to 53.44 mL/min/1.73 m 2 at 6 months, whereas the control group had a decrease from 43.4 mL/min/1.73 m 2 at baseline to 40.84 mL/min/1.73 m 2 at 6 months ( P = .03)
These changes push the body toward weight regain and persist for years after weight loss
Changes to the microbial phyla and genera observed in the 5A-1MQ-treated group switched from WD to LD could have been driven by additive, synergistic, or independent mechanisms relative to those induced by diet switch alone, which could not be determined with the current study design that lacked a group treated with 5A-1MQ and maintained on WD
In addition, GLP-1/glucagon and GLP-1/GIP dual receptor agonists and GLP-1/GIP/glucagon triple receptor agonists have shown the potential to reduce blood glucose levels and body weight through their effects on islets and peripheral tissues, improving beta cell function and stimulating energy expenditure
Appetite suppression often increases as the dose is slowly adjusted and the body adapts to the medication
