Research to date suggests it is generally well tolerated, with no serious adverse events reported during short- to mid-term use
Gene Regulation: Downregulates senescence markers like p16 (INK4a) and p21 (Waf1), delaying cellular aging
Evidence for loading protocols remains anecdotal, and many users achieve good results with consistent moderate dosing from day one
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This overproduction often shows up as dark patches, uneven tone, or spots
Moreover, blood Lys concentration was lower in the groups that received RPM in low CP diets, compared to the negative control groups (low CP without RPM supplementation) supporting the idea that Lys could have been the first-limiting AA for growth instead of Met (Inhuber et al., 2021)