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Then came Wegovy, a high-dose version officially marketed as an obesity treatment
Notably, semaglutide has also been associated with a 70% reduction in heart failure hospitalizations, highlighting its potential benefits beyond weight management
A balanced diet following evidence-based patterns such as the Mediterranean diet may support metabolic health and potentially reduce inflammation
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Months of lower body weight produce lasting benefits including improved insulin sensitivity, reduced hepatic fat, decreased inflammatory markers, and potentially improved cardiovascular remodeling
However, a drawback of these medicines has been the necessity for administration by subcutaneous injection, which limits patient utilization and may reduce opportunities for fixed-dose combination treatments with other small-molecule drugs
