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Sikiri P, Seiwerth S, Rucman R, et al
Liraglutide (Saxenda): The Original Weight Loss GLP-1 Liraglutide was the first GLP-1 receptor agonist to receive FDA approval specifically for chronic weight management, doing so in 2014 under the brand name Saxenda
Incretins augment insulin secretion in a glucose-dependent fashion, but their half-lives are very short, as they are rapidly cleared by DPP-4
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baseline 247.8 lb (Wegovy HD and placebo), 256.9 lb (Wegovy 2.4 mg), and BMI 39.9 kg/m 2 (N=1,407, randomized 5:1:1 to Wegovy HD injection 7.2 mg, Wegovy injection 2.4 mg, or placebo)
Protein: A macronutrient critical for building and repairing tissues, supporting immune function, and maintaining muscle mass
