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One of the main advantage of the gradual titration approach is its possibility to minimize side effects

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Furthermore, this mitochondrial dysfunction is intimately linked to the deactivation of the AMPK enzyme, the body's master metabolic switch, leaving patients trapped in a state of severe energy deficit and highly vulnerable to post-exertional malaise (PEM)

BMC Complementary and Alternative Medicine

Nutrient sensing in the gut: new roads to therapeutics

Signorelli, S