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The study was retrospective, relied on structured EHR data, and used coded definitions for recurrence rather than centrally adjudicated oncologic outcomes

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Mass spectrometry data analysis PatternLab for Proteomics v4.1.1.25 (PatternLab) 54 was used to perform peptide-spectrum matching against a Mus musculus proteome from UniProt (UP000000589, downloaded on 26 August 2020) and label-free quantitative analysis

Patients should pause further dose increases until symptoms have settled and discussed with their healthcare team