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Histological assays showed a lack of severe immune-cell infiltration in the liver of hepsin / mice compared to wild-type mice within 6 h post-APAP exposure, suggesting the need for further investigation of inflammation in hepsin-mediated APAP intoxication

Variants X(PC5)a and X(PC5)b showed partial cleavage of full-length procaspase-1, whereas X(PC5)c showed no detectable activity

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We explored a caliper width of 0.01, which approximately represented 0.2 times the standard deviation of the logit of the propensity scores, as suggested in prior publications 66