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Off-label prescribing is based on a healthcare provider's medical judgment, clinical experience, and evaluation of available scientific evidence
PMID: 26 LuYChanYTTanHYZhangCGuoWXuYet al
Rotating application sites is recommended to prevent irritation
In multiple rodent models of chronic stress (a shared risk factor for major psychiatric illnesses), administration of LAC leads to a rapid and persistent antidepressant-like response by increasing histone acetylation and expression of key genes, including mGlu2 receptors and the downstream brain-derived neurotrophic factor BDNF [27, 30, 34,35,36,37]
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