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Transdermal delivery systems may additionally cause local skin reactions , including redness, itching, or irritation at the application site

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Conclusions The serelaxin clinical trials failed to show significance due to several reasons, including patient selection, trial design, and the use of long-term clinical endpoints despite the short serelaxin administration

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10.1080/13813455.2018.1437186 91 SharmaR.BrownD.AwasthiS.YangY.SharmaA.PatrickB.et al (2004)