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RESULTS: Plasma and urine measurements indicated that the dye quickly distributed from the breast injection site to the circulation, with 32% of the total dose excreted in urine within 48 hours

This creates foam, traps peptide in bubbles, and generates mechanical stress that can denature protein molecules

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Kennedy, PhD, the Eshelman Distinguished Professor and chair of the University of North Carolina Eshelman School of Pharmacy

10.1007/s001250051445 29

Tikkanen I, Narko K, Zeller C, et al