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N Engl J Med 2021;384:9891002.ArticlePubMed 18

Additionally, the loss of muscle mass has been problematic for some individuals taking this class of medication, with lean body mass accounting for up to 1540% of total weight loss

Thats the difference between I should qualify and I submitted a case that can be approved. How to Build an Undeniable Case for Approval The strongest GLP-1 approvals dont happen because a patient asks for the medication convincingly

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The cardiovascular protective mechanisms of GLP-1 receptor agonists are thought to include: Improved glycaemic control , reducing endothelial dysfunction associated with hyperglycaemia Weight reduction , decreasing metabolic stress and inflammation Blood pressure lowering , potentially through effects on fluid balance and vascular function Favourable lipid profile changes , including modest reductions in LDL cholesterol and triglycerides Anti-inflammatory effects , reducing systemic markers of inflammation such as C-reactive protein [20] [21] Regulatory bodies including the MHRA and EMA have not identified thrombotic events as a specific safety concern with GLP-1 receptor agonists