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Further dose escalations occur monthly as tolerated, with maximum doses of 2.0 mg weekly for diabetes and 2.4 mg weekly for weight management
When retatrutide binds to GLP-1 receptors, it stimulates insulin release from the pancreas, reduces glucagon secretion, delays gastric emptying, and suppresses appetite through direct signaling to the brain
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GLP-1 RAs can effectively lower blood glucose levels and facilitate weight loss with a low risk of hypoglycemia
A helpful rule is: small meals, protein first, gentle fiber, steady fluids
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