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A broader review of the peptides relationship to the nitric oxide system describes its competing interactions with both L-arginine and L-arginine analogues across a range of experimental models [2]
So we do take a synthetic version of that
The magnesium connection is particularly well-established a 2018 review in the Journal of Osteopathic Medicine and a subsequent randomised trial confirmed the enzymatic dependency
Blood 96(11):717a, 2000
T.et al (2022)
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