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A 16.8% mean body weight reduction and a 2.0% absolute A1C drop over 40 weeks place retatrutide at the top of the class and give us the clearest picture yet of what triple agonism delivers in a controlled clinical setting

The specific thresholds that should prompt dose reduction or discontinuation include: ALT or AST elevation exceeding 3 times the patient's baseline value, new or worsening coagulopathy (INR increase of 0.5 or more from baseline), albumin decline below 2.5 g/dL, or new clinical signs of hepatic decompensation such as worsening ascites, encephalopathy, or jaundice [5]