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Int J Mol Sci (2021) 22(4):2110
By persistently reducing nutrient inflow while maintaining or redistributing oxidative demand, GLP-1RA therapy establishes a state of chronic energy flux constriction
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Studies also suggest that the peptide may stimulate appetite
GLP-1 medications, by contrast, actively reduce cardiovascular risk
But I think for most people, it's one of the reasons I say have guidelines, don't have rules
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