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A decrease in urinary melatonin in postmenopausal women was associated with sarcopenia, and in castrated male rats, the melatonin supply slowed muscle atrophy, operating as testosterone [58]

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Second, amplification of pro-inflammatory cytokine response in macrophages by S100A8/S100A9 complex is via activation of MAPK and NF-B signaling (128)

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